7OTN

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-247

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, A)	Reverse transcriptase/ribonuclease H	polymer	556	64022.4	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p66 RT
2	B, D (D, B)	Reverse transcriptase/ribonuclease H	polymer	428	50039.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p51 RT
3	E, G (E, T)	DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3')	polymer	27	8383.4	2		Human immunodeficiency virus type 1 BH10
4	F, H (F, P)	DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3')	polymer	21	6474.3	2		Homo sapiens
5	I, K (C, A)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
6	J, L (C, A)	(S)-2-((2-(6-amino-9H-purin-9-yl)ethyl)amino)-3-phosphonopropanoic acid	non-polymer		330.2	2	Chemie (1IH)
7	M (D)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

C, A: 1 - 554 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	initiating methionine
Val 0	-	expression tag
Cys 258	Gln 857	conflict
Ser 280	Cys 879	conflict
Asn 498	Asp 1097	conflict

D, B: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257839.1
Non-Polymers*	Number of molecules	4
	Total formula weight	770.4
All*	Total formula weight	258609.5

*Water molecules are not included.