8OXP
| ATM(Q2971A) in complex with Mg AMP-PNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... | 著者 | Howes, A.C, Perisic, O, Williams, R.L. | 登録日 | 2023-05-02 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
|
|
8OXQ
| ATM(Q2971A) dimeric C-terminal region in complex with Mg AMP-PNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... | 著者 | Howes, A.C, Perisic, O, Williams, R.L. | 登録日 | 2023-05-02 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
|
|
8OXM
| ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide | 分子名称: | Cellular tumor antigen p53, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Howes, A.C, Perisic, O, Williams, R.L. | 登録日 | 2023-05-02 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
|
|
8OXO
| ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide | 分子名称: | Cellular tumor antigen p53, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Howes, A.C, Perisic, O, Williams, R.L. | 登録日 | 2023-05-02 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress. Sci Adv, 9, 2023
|
|
3UR4
| Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | 著者 | Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-21 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
|
|
3C9W
| Crystal Structure of ERK-2 with hypothemycin covalently bound | 分子名称: | (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione, Mitogen-activated protein kinase 1 | 著者 | Rosenfeld, R.J. | 登録日 | 2008-02-18 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular modeling and crystal structure of ERK2-hypothemycin complexes J.Struct.Biol., 164, 2008
|
|
6GHB
| |
3UVO
| Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | 分子名称: | Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5 | 著者 | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | 登録日 | 2011-11-30 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
|
|
1MD0
| |
3UVM
| Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 | 分子名称: | Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 | 著者 | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | 登録日 | 2011-11-30 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
|
|
3ZU7
| |
3ZUV
| |
7C62
| |
3B38
| Structure of A104V DJ-1 | 分子名称: | 1,2-ETHANEDIOL, Protein DJ-1 | 著者 | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | 登録日 | 2007-10-19 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
|
|
3B36
| Structure of M26L DJ-1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1 | 著者 | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | 登録日 | 2007-10-19 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
|
|
8HZC
| |
8HZB
| |
1QYM
| X-ray structure of human gankyrin | 分子名称: | 26S proteasome non-ATPase regulatory subunit 10 | 著者 | Manjasetty, B.A, Quedenau, C, Sievert, V, Buessow, K, Niesen, F, Delbrueck, H, Heinemann, U. | 登録日 | 2003-09-11 | 公開日 | 2003-11-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins, 55, 2004
|
|
8HZS
| |
6XYO
| Multiple system atrophy Type I alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
|
|
5WXN
| Structure of the LKB1 and 14-3-3 complex | 分子名称: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase STK11 | 著者 | Ding, S, Shi, Z.B. | 登録日 | 2017-01-08 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta Acta Crystallogr F Struct Biol Commun, 73, 2017
|
|
8JEX
| Cryo-EM structure of alpha-synuclein gS87 fibril | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein, unverified amino acid chain | 著者 | Xia, W.C, Sun, Y.P, Liu, C. | 登録日 | 2023-05-16 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures. Nat Commun, 15, 2024
|
|
5X3F
| Crystal structure of the YgjG-Protein A-Zpa963-PKA catalytic domain | 分子名称: | Putrescine aminotransferase,Immunoglobulin G-binding protein A, Zpa963,cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Youn, S.J, Kwon, N.Y, Lee, J.H, Kim, J.H, Lee, H, Lee, J.O. | 登録日 | 2017-02-05 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | 主引用文献 | Construction of novel repeat proteins with rigid and predictable structures using a shared helix method. Sci Rep, 7, 2017
|
|
7JVR
| Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
|
|
4ARZ
| The crystal structure of Gtr1p-Gtr2p complexed with GTP-GDP | 分子名称: | GTP-BINDING PROTEIN GTR1, GTP-BINDING PROTEIN GTR2, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Jeong, J.H, Kim, Y.G. | 登録日 | 2012-04-27 | 公開日 | 2012-07-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal Structure of the Gtr1Pgtp-Gtr2Pgdp Complex Reveals Large Structural Rearrangements Triggered by GTP-to-Gdp Conversion J.Biol.Chem., 287, 2012
|
|