Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B

Summary for 3UVO

Related3UVK 3UVL 3UVM 3UVN
DescriptorWD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B (3 entities in total)
Functional Keywordstrithorax, chromatin biology, beta-propeller, scaffolding, histone h3, nucleus, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P61964
Nucleus speckle Q9UPS6
Total number of polymer chains2
Total molecular weight35998.78
Zhang, P.,Lee, H.,Brunzelle, J.S.,Couture, J.-F. (deposition date: 2011-11-30, release date: 2011-12-14, Last modification date: 2012-05-30)
Primary citation
Zhang, P.,Lee, H.,Brunzelle, J.S.,Couture, J.F.
The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.
Nucleic Acids Res., 40:4237-4246, 2012
PubMed: 22266653 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkr1235
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2194 0.7% 3.1% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02