PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

---

7B7S	CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368 分子名称: 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2020-12-11 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo. J.Med.Chem., 64, 2021
2X5Y	Human ZC3HAV1 (ARTD13), C-terminal domain 分子名称: ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1 著者 Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Kraulis, P, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H. 登録日 2010-02-11 公開日 2010-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Structural Basis for Lack of Adp-Ribosyltransferase Activity in Poly(Adp-Ribose) Polymerase-13/Zinc Finger Antiviral Protein. J.Biol.Chem., 290, 2015
8Q7I	PCNA from Chaetomium thermophilum in complex with Fen1 peptide 分子名称: Flap endonuclease 1, Proliferating cell nuclear antigen, SODIUM ION 著者 Alphey, M.S, Wolford, C.B, MacNeill, S.A. 登録日 2023-08-16 公開日 2023-12-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA. Front Mol Biosci, 10, 2023
8P9O	PCNA from Chaetomium thermophilum in complex with PolD3 peptide 分子名称: Proliferating cell nuclear antigen, Synthetic peptide corresponding to amino acids 437 to 451 of PolD3 from Chaetomium thermophilum 著者 Alphey, M.S, Wolford, C.B, MacNeill, S.A. 登録日 2023-06-06 公開日 2023-12-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA. Front Mol Biosci, 10, 2023
1G3N	STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX 分子名称: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE 6 INHIBITOR, V-CYCLIN 著者 Jeffrey, P.D, Tong, L, Pavletich, N.P. 登録日 2000-10-24 公開日 2001-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev., 14, 2000
1R2P	Solution structure of domain 5 from the ai5(gamma) group II intron 分子名称: 34-MER 著者 Sigel, R.K.O, Sashital, D.G, Abramovitz, D.L, Palmer III, A.G, Butcher, S.E, Pyle, A.M. 登録日 2003-09-29 公開日 2004-02-03 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif. Nat.Struct.Mol.Biol., 11, 2004
1LKI	THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING 分子名称: LEUKEMIA INHIBITORY FACTOR 著者 Robinson, R.C, Grey, L.M, Staunton, D, Stuart, D.I, Heath, J.K, Jones, E.Y. 登録日 1994-12-12 公開日 1995-03-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell(Cambridge,Mass.), 77, 1994
1E0O	CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX 分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ... 著者 Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L. 登録日 2000-04-03 公開日 2000-10-23 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin Nature, 407, 2000
2PLV	STRUCTURAL FACTORS THAT CONTROL CONFORMATIONAL TRANSITIONS AND SEROTYPE SPECIFICITY IN TYPE 3 POLIOVIRUS 分子名称: HUMAN POLIOVIRUS TYPE 1 (SUBUNIT VP1), HUMAN POLIOVIRUS TYPE 1 (SUBUNIT VP2), HUMAN POLIOVIRUS TYPE 1 (SUBUNIT VP3), ... 著者 Filman, D.J, Hogle, J.M. 登録日 1989-10-17 公開日 1989-10-17 最終更新日 2023-04-19 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus EMBO J., 8, 1989
2LQK	NMR solution structure of the N-terminal domain of the CdnL protein from Thermus thermophilus 分子名称: Transcriptional regulator 著者 Jimenez, M, Padmanabhan, S. 登録日 2012-03-09 公開日 2012-08-01 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR structure note: N-terminal domain of Thermus thermophilus CdnL. J.Biomol.Nmr, 53, 2012
2LZP	Structure of NS2(2-32) GBVB protein 分子名称: NS2 peptide 著者 Montserret, R, Penin, F, Martin, A. 登録日 2012-10-08 公開日 2014-04-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies. J.Virol., 88, 2014
2MKB	Structure of NS2(113-137) GBVB protein 分子名称: Protease NS2-3 著者 Montserret, R, Martin, A, Penin, F. 登録日 2014-02-04 公開日 2014-05-07 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies. J.Virol., 88, 2014
4GAT	SOLUTION NMR STRUCTURE OF THE WILD TYPE DNA BINDING DOMAIN OF AREA COMPLEXED TO A 13BP DNA CONTAINING A CGATA SITE, REGULARIZED MEAN STRUCTURE 分子名称: DNA (5'-D(*CP*AP*GP*CP*GP*AP*TP*AP*GP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*CP*TP*AP*TP*CP*GP*CP*TP*G)-3'), NITROGEN REGULATORY PROTEIN AREA, ... 著者 Clore, G.M, Starich, M, Wikstrom, M, Gronenborn, A.M. 登録日 1997-11-07 公開日 1998-01-28 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The solution structure of a fungal AREA protein-DNA complex: an alternative binding mode for the basic carboxyl tail of GATA factors. J.Mol.Biol., 277, 1998
1TFB	NMR STUDIES OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIB: DYNAMICS AND INTERACTION WITH VP16 ACTIVATION DOMAIN, 20 STRUCTURES 分子名称: TFIIB 著者 Bagby, S, Ikura, M. 登録日 1996-11-14 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain. Biochemistry, 37, 1998
2LZQ	Structure of NS2(32-57) GBVB protein 分子名称: NS2 peptide 著者 Montserret, R, Penin, F, Martin, A. 登録日 2012-10-08 公開日 2014-04-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies. J.Virol., 88, 2014
4CXA	Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP 分子名称: CYCLIN-DEPENDENT KINASE 12, CYCLIN-K, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Nowak, R, Goubin, S, Mahajan, R.P, Kopec, J, Froese, S, Tallant, C, Carpenter, E.P, Mackenzie, A, Faust, B, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A.M, Bountra, C, Bullock, A. 登録日 2014-04-04 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding. Sci.Rep., 5, 2015
4CXF	Structure of CnrH in complex with the cytosolic domain of CnrY 分子名称: CHLORIDE ION, CNRY, RNA POLYMERASE SIGMA FACTOR CNRH, ... 著者 Maillard, A.P, Girard, E, Ziani, W, Petit-Hartlein, I, Kahn, R, Coves, J. 登録日 2014-04-07 公開日 2014-04-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The Crystal Structure of the Anti-Sigma Factor Cnry in Complex with the Sigma Factor Cnrh Shows a New Structural Class of Anti- Sigma Factors Targeting Extracytoplasmic-Function Sigma Factors. J.Mol.Biol., 426, 2014
1DM2	HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE 分子名称: 1,2-ETHANEDIOL, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, CYCLIN-DEPENDENT KINASE 2 著者 Thunnissen, A.M, Kim, S.-H. 登録日 1999-12-13 公開日 2000-05-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol., 7, 2000
7TA5	Crystal structure of cyanophycin synthetase 2 from Gloeothece citriformis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, D(-)-TARTARIC ACID, ... 著者 Sharon, I, Schmeing, T.M. 登録日 2021-12-20 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and Function of the beta-Asp-Arg Polymerase Cyanophycin Synthetase 2. Acs Chem.Biol., 17, 2022
2XPL	Crystal structure of Iws1(Spn1) conserved domain from Encephalitozoon cuniculi 分子名称: CHLORIDE ION, IWS1 著者 Koch, M, Diebold, M.-L, Cura, V, Cavarelli, J, Romier, C. 登録日 2010-08-27 公開日 2010-11-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The Structure of an Iws1/Spt6 Complex Reveals an Interaction Domain Conserved in Tfiis, Elongin a and Med26 Embo J., 29, 2010
3HH2	Crystal structure of the myostatin:follistatin 288 complex 分子名称: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ... 著者 Cash, J.N, Thompson, T.B. 登録日 2009-05-14 公開日 2009-08-04 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding Embo J., 28, 2009
2A4L	Human cyclin-dependent kinase 2 in complex with roscovitine 分子名称: Homo sapiens cyclin-dependent kinase 2, R-ROSCOVITINE 著者 De Azevedo Jr, W.F, Kim, S.H. 登録日 2005-06-29 公開日 2006-10-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur.J.Biochem., 243, 1997
4CFV	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylphenol, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-19 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
4CFM	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 6-(cyclohexylmethoxy)-8-(2-methylphenyl)-9H-purin-2-amine, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-18 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
4CFW	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylbenzenesulfonamide, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-19 公開日 2013-12-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

<231232233234235236237238239240241242243244245246>