7B7S

CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368

Summary for 7B7S

Entry DOI	10.2210/pdb7b7s/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2, 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, ... (7 entities in total)
Functional Keywords	cyclin-dependent kinase, flt3, acute myeloid leukemia, inhibition, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	128646.66
Authors	Djukic, S.,Skerlova, J.,Rezacova, P. (deposition date: 2020-12-11, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Dayal, N.,Reznickova, E.,Hernandez, D.E.,Perina, M.,Torregrosa-Allen, S.,Elzey, B.D.,Skerlova, J.,Ajani, H.,Djukic, S.,Vojackova, V.,Lepsik, M.,Rezacova, P.,Krystof, V.,Jorda, R.,Sintim, H.O. 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo. J.Med.Chem., 64:10981-10996, 2021 Cited by PubMed: 34288692 DOI: 10.1021/acs.jmedchem.1c00330 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation