7B7S
CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | Cyclin-A,Cyclin A |
| 3 | E, H (A, C) | 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide | non-polymer | 391.4 | 2 | Chemie (T1T) | |||
| 4 | F, I (A, C) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 5 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | J (D) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 1 | Chemie (SGM) | |||
| 7 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127535.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1111.0 | |
| All* | Total formula weight | 128646.7 |
