4CXA

Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP

Summary for 4CXA

Entry DOI	10.2210/pdb4cxa/pdb
Descriptor	CYCLIN-DEPENDENT KINASE 12, CYCLIN-K, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
Functional Keywords	transferase, kinase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus: Q9NYV4 O75909
Total number of polymer chains	4
Total formula weight	140832.34
Authors	Dixon Clarke, S.E.,Elkins, J.M.,Pike, A.C.W.,Nowak, R.,Goubin, S.,Mahajan, R.P.,Kopec, J.,Froese, S.,Tallant, C.,Carpenter, E.P.,Mackenzie, A.,Faust, B.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2014-04-04, release date: 2014-05-21, Last modification date: 2023-12-20)
Primary citation	Dixon-Clarke, S.E.,Elkins, J.M.,Cheng, S.G.,Morin, G.B.,Bullock, A.N. Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding. Sci.Rep., 5:17122-, 2015 Cited by PubMed: 26597175 DOI: 10.1038/SREP17122 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation