4CXA
Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | CYCLIN-DEPENDENT KINASE 12 | polymer | 340 | 39719.9 | 2 | UniProt (Q9NYV4) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CDC2-RELATED KINASE, ARGININE/SERINE-RICH, CRKRS, CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7, CDC2-RELATED PROTEIN KINASE 7, CELL DIVISION PROTEIN KINASE 12, HCDK12, CDK12 |
| 2 | B, D (B, D) | CYCLIN-K | polymer | 259 | 30443.1 | 2 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) | HOMO SAPIENS (HUMAN) | CCNK |
| 3 | E (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) |
Sequence modifications
A, C: 715 - 1052 (UniProt: Q9NYV4)
B, D: 11 - 267 (UniProt: O75909)
| PDB | External Database | Details |
|---|---|---|
| Ser 713 | - | expression tag |
| Met 714 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 9 | - | expression tag |
| Met 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140326.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.2 | |
| All* | Total formula weight | 140832.3 |
