5NQT
| Tubulin Darpin room-temperature structure determined by serial millisecond crystallography | 分子名称: | DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Weinert, T, Olieric, N, James, D, Gashi, D, Nogly, P, Jaeger, K, Steinmetz, M.O, Standfuss, J. | 登録日 | 2017-04-21 | 公開日 | 2017-09-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons. Nat Commun, 8, 2017
|
|
5O09
| BtubABC mini microtubule | 分子名称: | Bacterial kinesin light chain, GUANOSINE-5'-DIPHOSPHATE, Tubulin, ... | 著者 | Deng, X, Bharat, T.A.M, Lowe, J. | 登録日 | 2017-05-16 | 公開日 | 2017-07-19 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Four-stranded mini microtubules formed by Prosthecobacter BtubAB show dynamic instability. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5OAM
| Molecular basis of human kinesin-8 function and inhibition | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF18A, ... | 著者 | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | 登録日 | 2017-06-23 | 公開日 | 2017-10-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural basis of human kinesin-8 function and inhibition. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5O7A
| Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin | 分子名称: | (2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Sharma, A, Olieric, N, Steinmetz, M.O. | 登録日 | 2017-06-08 | 公開日 | 2017-07-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | 主引用文献 | Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin. Int J Mol Sci, 18, 2017
|
|
5OCU
| Molecular basis of human kinesin-8 function and inhibition | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF18A, ... | 著者 | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | 登録日 | 2017-07-03 | 公開日 | 2017-10-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Structural basis of human kinesin-8 function and inhibition. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5OGC
| Molecular basis of human kinesin-8 function and inhibition | 分子名称: | 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Locke, J, Joseph, A.P, Topf, M, Moores, C.A. | 登録日 | 2017-07-12 | 公開日 | 2017-10-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of human kinesin-8 function and inhibition. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5OSK
| Tubulin-7j complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(2,5-Dimethoxybenzyl)-7-sulfamoyloxy-6-methoxy-3,4-dihydroquinazolin-2(1H)-one, CALCIUM ION, ... | 著者 | Menchon, G, Prota, A.E, Steinmetz, M.O, Potter, B.V.L. | 登録日 | 2017-08-17 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. J. Med. Chem., 61, 2018
|
|
5OV7
| tubulin - rigosertib complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Menchon, G, Prota, A.E, Steinmetz, M, Jost, M. | 登録日 | 2017-08-28 | 公開日 | 2017-10-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | 主引用文献 | Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol. Cell, 68, 2017
|
|
7YHN
| ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | 登録日 | 2022-07-14 | 公開日 | 2023-07-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem., 65, 2022
|
|
7YOP
| |
7Z01
| Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex | 分子名称: | 2-methoxy-5-[2-(5,6,7-trimethoxy-1,3-benzothiazol-2-yl)ethyl]phenol, CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J, Steinmetz, M. | 登録日 | 2022-02-21 | 公開日 | 2022-03-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. J.Am.Chem.Soc., 144, 2022
|
|
7Z02
| Z-SBTub2M photoswitch bound to tubulin-DARPin D1 complex | 分子名称: | 6-methyl-2-[2-(3,4,5-trimethoxyphenyl)ethyl]-1,3-benzothiazole, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J, Steinmetz, M. | 登録日 | 2022-02-21 | 公開日 | 2022-03-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. J.Am.Chem.Soc., 144, 2022
|
|
7Z7D
| Tubulin-Todalam-Vinblastine-complex | 分子名称: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O. | 登録日 | 2022-03-15 | 公開日 | 2022-04-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7Z6S
| |
7Z2P
| Tubulin-nocodazole complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O. | 登録日 | 2022-02-28 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
|
|
7Z2N
| Tubulin-18-complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O. | 登録日 | 2022-02-28 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
|
|
7Z2A
| P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-10-19 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
|
|
7Z2C
| P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-10-19 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
|
|
7Z2B
| P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | 登録日 | 2022-02-26 | 公開日 | 2022-11-16 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
|
|
7ZCW
| Cryo-EM structure of GMPCPP-microtubules in complex with VASH2-SVBP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Choi, S.R, Blum, T, Steinmetz, M.O. | 登録日 | 2022-03-29 | 公開日 | 2022-12-14 | 最終更新日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules. J.Cell Biol., 222, 2023
|
|
7YYZ
| Molecular snapshots of drug release from tubulin: 10 microseconds after photoactivation. | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J. | 登録日 | 2022-02-18 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14, 2023
|
|
7YZ1
| Molecular snapshots of drug release from tubulin: 1 millisecond after photoactivation. | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J. | 登録日 | 2022-02-18 | 公開日 | 2023-02-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14, 2023
|
|
7YYX
| Molecular snapshots of drug release from tubulin: 100 nanoseconds after photoactivation. | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J. | 登録日 | 2022-02-18 | 公開日 | 2023-02-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14, 2023
|
|
7YYQ
| Molecular snapshots of drug release from tubulin: Dark state | 分子名称: | Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J. | 登録日 | 2022-02-18 | 公開日 | 2023-02-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14, 2023
|
|
7YYV
| Molecular snapshots of drug release from tubulin: 1 nanosecond after photoactivation. | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | 著者 | Wranik, M, Weinert, T, Standfuss, J. | 登録日 | 2022-02-18 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14, 2023
|
|