7E4Z
Crystal structure of tubulin in complex with Maytansinol
Summary for 7E4Z
Entry DOI | 10.2210/pdb7e4z/pdb |
Descriptor | Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, (1R,2S,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaene-8,23-dione, ... (13 entities in total) |
Functional Keywords | microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Bos taurus (Bovine) More |
Total number of polymer chains | 6 |
Total formula weight | 259362.50 |
Authors | |
Primary citation | Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J. C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566:197-203, 2021 Cited by PubMed: 34144258DOI: 10.1016/j.bbrc.2021.05.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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