6XES

Tubulin-RB3_SLD in complex with compound 40a

Summary for 6XES

Entry DOI	10.2210/pdb6xes/pdb
Descriptor	Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (10 entities in total)
Functional Keywords	microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	5
Total formula weight	214872.83
Authors	White, S.W.,Yun, M. (deposition date: 2020-06-13, release date: 2021-08-25, Last modification date: 2023-10-18)
Primary citation	Chen, H.,Deng, S.,Albadari, N.,Yun, M.K.,Zhang, S.,Li, Y.,Ma, D.,Parke, D.N.,Yang, L.,Seagroves, T.N.,White, S.W.,Miller, D.D.,Li, W. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents. J.Med.Chem., 64:12049-12074, 2021 Cited by PubMed: 34378386 DOI: 10.1021/acs.jmedchem.1c00715 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation