7DAE
EPB in complex with tubulin
Summary for 7DAE
Entry DOI | 10.2210/pdb7dae/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, ... (13 entities in total) |
Functional Keywords | phomopsin a, tubulin, protein-drug complex, cell cycle |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 265260.43 |
Authors | |
Primary citation | Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y. High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design. Biochem.Biophys.Res.Commun., 534:330-336, 2021 Cited by PubMed: 33272565DOI: 10.1016/j.bbrc.2020.11.082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.394 Å) |
Structure validation
Download full validation report