7E4R

Crystal structure of tubulin in complex with D-DM1-SMe

Summary for 7E4R

Entry DOI	10.2210/pdb7e4r/pdb
Descriptor	Tubulin alpha-1B chain, (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl)propanoyl)-D-alaninate, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	6
Total formula weight	258498.85
Authors	Wang, Y.,Li, W. (deposition date: 2021-02-15, release date: 2021-07-07, Last modification date: 2023-11-29)
Primary citation	Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J. C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566:197-203, 2021 Cited by PubMed: 34144258 DOI: 10.1016/j.bbrc.2021.05.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.597 Å)

Structure validation