7E4Q

Crystal structure of tubulin in complex with L-DM1-SMe

Summary for 7E4Q

Entry DOI	10.2210/pdb7e4q/pdb
Descriptor	Tubulin alpha-1B chain, (1S,2R,3R,5R,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methyldisulfanyl)propanoyl]amino}propanoate (non-preferred name), PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	microtubule assembly inhibitors, structural protein
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	6
Total formula weight	258523.15
Authors	Wang, Y.,Li, W. (deposition date: 2021-02-14, release date: 2021-07-07, Last modification date: 2023-11-29)
Primary citation	Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J. C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566:197-203, 2021 Cited by PubMed: 34144258 DOI: 10.1016/j.bbrc.2021.05.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.501 Å)

Structure validation