7DAF

IXA in complex with tubulin

Summary for 7DAF

• Entry DOI: 10.2210/pdb7daf/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (1~{S},3~{S},7~{S},10~{R},11~{S},12~{S},16~{R})-8,8,10,12,16-pentamethyl-3-[(~{E})-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-7,11-bis(oxidanyl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, ... (13 entities in total)
• Functional Keywords: tubulin, protein-drug complex, cell cycle
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 265308.06

Authors

Wu, C.,Wang, Y. (deposition date: 2020-10-16, release date: 2021-03-24, Last modification date: 2023-11-29)

• Primary citation: Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y.; High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.; Biochem.Biophys.Res.Commun., 534:330-336, 2021; PubMed: 33272565; DOI: 10.1016/j.bbrc.2020.11.082

Experimental method

X-RAY DIFFRACTION (2.4 Å)