PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5R9Z	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13502a in complex with MAP kinase p38-alpha 分子名称: 2-[(4-chlorophenyl)amino]benzamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-04 公開日 2020-07-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
4I80	Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics 分子名称: Menin, macrocyclic peptidomimetic 著者 Huang, J, Lei, M. 登録日 2012-12-01 公開日 2013-03-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction. J.Med.Chem., 56, 2013
4IQJ	Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome 分子名称: DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*GP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DOC))-3'), ... 著者 Liu, B, Lin, J, Steitz, T. 登録日 2013-01-11 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome Structure, 21, 2013
6XU2	Human karyopherin RanBP5 (isoform-3) 分子名称: Antipain, Importin-5, NICKEL (II) ION 著者 Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T. 登録日 2020-01-17 公開日 2020-04-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.834 Å) 主引用文献 X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
6XTE	Human karyopherin RanBP5 (isoform-1) 分子名称: Antipain, CHLORIDE ION, Importin-5, ... 著者 Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T. 登録日 2020-01-16 公開日 2020-04-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
2JZ3	SOCS box elonginBC ternary complex 分子名称: Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 著者 Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. 登録日 2007-12-27 公開日 2008-09-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase J.Mol.Biol., 381, 2008
5JZE	Erve virus viral OTU domain protease in complex with mouse ISG15 分子名称: CITRATE ANION, RNA-dependent RNA polymerase, Ubiquitin-like protein ISG15, ... 著者 Deaton, M.K, Dzimianski, J.V, Pegan, S.D. 登録日 2016-05-16 公開日 2016-10-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species. J.Virol., 90, 2016
5C2K	Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP 分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Murayama, K, Kato-Murayama, M, Hosaka, T, Kitamura, T, Yokoyama, S, Shirouzu, M. 登録日 2015-06-16 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structural basis of G-protein target alternation of MgcRacGAP by phospholylation To Be Published
7ZY4	Crystal structure of human CstF77 in complex with hFip1 分子名称: Cleavage stimulation factor subunit 3, GLYCEROL, hFip1 著者 Muckenfuss, L.M, Jinek, M. 登録日 2022-05-23 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Elife, 11, 2022
8FLK	Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 分子名称: 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP 著者 Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. 登録日 2022-12-21 公開日 2023-11-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
8FLM	Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 分子名称: 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... 著者 Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. 登録日 2022-12-21 公開日 2023-11-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
3H7H	Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273) 分子名称: BETA-MERCAPTOETHANOL, Transcription elongation factor SPT4, Transcription elongation factor SPT5, ... 著者 Wenzel, S, Wohrl, B.M, Rosch, P, Martins, B.M. 登録日 2009-04-27 公開日 2009-12-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface Biochem.J., 425, 2010
6UEI	Crystal structure of human zinc finger antiviral protein 分子名称: ZINC ION, Zinc finger CCCH-type antiviral protein 1 著者 Meagher, J.L, Smith, J.L. 登録日 2019-09-21 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences. Proc.Natl.Acad.Sci.USA, 116, 2019
6B3E	Crystal structure of human CDK12/CyclinK in complex with an inhibitor 分子名称: 1,2-ETHANEDIOL, 2-[(2S)-1-(6-{[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]amino}-9-ethyl-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol, Cyclin-K, ... 著者 Ferguson, A.D. 登録日 2017-09-21 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem, 13, 2018
6UX2	Crystal structure of ZIKV RdRp in complex with STAT2 分子名称: Nonstructural Protein 5, SULFATE ION, Signal transducer and activator of transcription 2, ... 著者 Wang, B, Song, J. 登録日 2019-11-06 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Structural basis for STAT2 suppression by flavivirus NS5. Nat.Struct.Mol.Biol., 27, 2020
2GD7	The Structure of the Cyclin T-binding domain of Hexim1 reveals the molecular basis for regulation of transcription elongation 分子名称: HEXIM1 protein 著者 Dames, S.A. 登録日 2006-03-15 公開日 2007-06-12 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb. Proc.Natl.Acad.Sci.Usa, 104, 2007
1RVF	FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS 分子名称: FAB 17-IA, HUMAN RHINOVIRUS 14 COAT PROTEIN 著者 Smith, T.J. 登録日 1996-09-05 公開日 1998-02-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon. Nature, 383, 1996
4F7T	Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PB1 (498-505) 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... 著者 Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. 登録日 2012-05-16 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
1TZY	Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution 分子名称: CHLORIDE ION, HISTONE H3, HISTONE H4-VI, ... 著者 Wood, C.M, Nicholson, J.M, Chantalat, L, Reynolds, C.D, Lambert, S.J, Baldwin, J.P. 登録日 2004-07-12 公開日 2004-08-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 High-resolution structure of the native histone octamer. Acta Crystallogr.,Sect.F, 61, 2005
1B72	PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX 分子名称: DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ... 著者 Piper, D.E, Batchelor, A.H, Chang, C.-P, Cleary, M.L, Wolberger, C. 登録日 1999-01-27 公開日 1999-02-19 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell(Cambridge,Mass.), 96, 1999
1VRH	HRV14/SDZ 880-061 COMPLEX 分子名称: 2-[4-(2H-1,4-BENZOTHIAZINE-3-YL)-PIPERAZINE-1-LY]-1,3-THIAZOLE-4-CARBOXYLIC ACID ETHYLESTER, RHINOVIRUS 14 著者 Oren, D.A, Zhang, A, Arnold, E. 登録日 1996-02-26 公開日 1997-02-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14. J.Mol.Biol., 259, 1996
6EQY	4th KOW domain of human hSpt5 分子名称: Transcription elongation factor SPT5 著者 Zuber, P.K, Schweimer, K, Roesch, P, Woehrl, B.M. 登録日 2017-10-16 公開日 2018-10-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF. Sci Rep, 8, 2018
7AHX	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR WITH BOUND MANGANESE 分子名称: D-Aspartate Tenofovir, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... 著者 Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. 登録日 2020-09-25 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021
7AII	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE 分子名称: DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ... 著者 Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. 登録日 2020-09-27 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021
7AIG	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-GLUTAMATE TENOFOVIR 分子名称: DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ... 著者 Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. 登録日 2020-09-27 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021

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