7AII
HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE
Summary for 7AII
Entry DOI | 10.2210/pdb7aii/pdb |
Descriptor | Gag-Pol polyprotein, DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), ... (7 entities in total) |
Functional Keywords | reverse transcriptase, rt inhibitor complex, tenofovir analog, rt-dna complex, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Total number of polymer chains | 8 |
Total formula weight | 258895.68 |
Authors | Gu, W.,Martinez, S.E.,Nguyen, H.,Xu, H.,Herdewijn, P.,de Jonghe, S.,Das, K. (deposition date: 2020-09-27, release date: 2021-01-13, Last modification date: 2024-01-31) |
Primary citation | Gu, W.,Martinez, S.,Nguyen, H.,Xu, H.,Herdewijn, P.,De Jonghe, S.,Das, K. Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64:782-796, 2021 Cited by PubMed: 33356231DOI: 10.1021/acs.jmedchem.0c01747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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