7AII

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
C	0003676	molecular_function	nucleic acid binding
C	0003964	molecular_function	RNA-directed DNA polymerase activity
C	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
C	0006278	biological_process	RNA-templated DNA biosynthetic process
D	0003964	molecular_function	RNA-directed DNA polymerase activity
D	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
B	ASP110
B	ASP185
B	ASP186
D	ASP110
D	ASP185
D	ASP186

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for RT p66/p51 heterodimerization

Chain	Residue	Details
B	TRP401
B	TRP414
D	TRP401
D	TRP414
C	ASP443
C	GLU478
C	ASN498
C	ASP549

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Essential for RT p66/p51 heterodimerization

Chain	Residue	Details
A	TRP401
A	TRP414
C	TRP401
C	TRP414

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by viral protease; partial

Chain	Residue	Details
A	PHE440
C	PHE440

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