7AII

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Gag-Pol polyprotein	polymer	556	64022.4	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 BH10	Pr160Gag-Pol
2	B, D (B, D)	Gag-Pol polyprotein	polymer	428	50039.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 BH10	Pr160Gag-Pol
3	E, G (T, E)	DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3')	polymer	27	8383.4	2		Human immunodeficiency virus type 1 BH10
4	F, H (P, F)	DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3')	polymer	21	6474.3	2		Homo sapiens
5	I, J, L, M (A, C)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
6	K, N (A, C)	L-Methionine Tenofovir	non-polymer		418.4	2	Chemie (RFE)
7	O, P, Q, R, S... (A, B, C, D, T...)	water	water		18.0	115	Chemie (HOH)

Sequence modifications

A, C: 1 - 554 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	initiating methionine
Val 0	-	expression tag
Cys 258	Gln 857	engineered mutation
Ser 280	Cys 879	engineered mutation
Asn 498	Asp 1097	engineered mutation

B, D: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257839.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1056.6
All*	Total formula weight	258895.7

*Water molecules are not included.