8FLM

Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53

Summary for 8FLM

• Entry DOI: 10.2210/pdb8flm/pdb
• EMDB information: 29281 29282
• Descriptor: Stimulator of interferon genes protein, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, cGAMP, ... (4 entities in total)
• Functional Keywords: sting, innate immunity, molecular glue, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 161399.23

Authors

Li, J.,Canham, S.M.,Zhang, X.,Bai, X.,Feng, Y. (deposition date: 2022-12-21, release date: 2023-11-01, Last modification date: 2024-03-13)

• Primary citation: Li, J.,Canham, S.M.,Wu, H.,Henault, M.,Chen, L.,Liu, G.,Chen, Y.,Yu, G.,Miller, H.R.,Hornak, V.,Brittain, S.M.,Michaud, G.A.,Tutter, A.,Broom, W.,Digan, M.E.,McWhirter, S.M.,Sivick, K.E.,Pham, H.T.,Chen, C.H.,Tria, G.S.,McKenna, J.M.,Schirle, M.,Mao, X.,Nicholson, T.B.,Wang, Y.,Jenkins, J.L.,Jain, R.K.,Tallarico, J.A.,Patel, S.J.,Zheng, L.,Ross, N.T.,Cho, C.Y.,Zhang, X.,Bai, X.C.,Feng, Y.; Activation of human STING by a molecular glue-like compound.; Nat.Chem.Biol., 20:365-372, 2024; PubMed: 37828400; DOI: 10.1038/s41589-023-01434-y

Experimental method

ELECTRON MICROSCOPY (2.9 Å)