8FLM
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Stimulator of interferon genes protein | polymer | 354 | 39553.4 | 4 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | E, H (A, C) | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid | non-polymer | 427.5 | 2 | Chemie (Y6H) | |||
| 3 | F, J (B, D) | cGAMP | non-polymer | 674.4 | 2 | Chemie (1SY) | |||
| 4 | G, I (B, C) | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide | non-polymer | 490.9 | 2 | Chemie (9IM) |
Sequence modifications
A, B, C, D: 1 - 344 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Arg 232 | His 232 | conflict |
| Thr 345 | - | expression tag |
| Ser 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Gly 348 | - | expression tag |
| Leu 349 | - | expression tag |
| Glu 350 | - | expression tag |
| Val 351 | - | expression tag |
| Leu 352 | - | expression tag |
| Phe 353 | - | expression tag |
| Gln 354 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 158213.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3185.6 | |
| All* | Total formula weight | 161399.2 |
