7AIG

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-GLUTAMATE TENOFOVIR

Summary for 7AIG

• Entry DOI: 10.2210/pdb7aig/pdb
• Descriptor: Gag-Pol polyprotein, DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), ... (6 entities in total)
• Functional Keywords: reverse transcriptase, rt inhibitor complex, tenofovir analog, rt-dna complex, transferase
• Biological source: Human immunodeficiency virus type 1 BH10; More
• Total number of polymer chains: 8
• Total formula weight: 258255.44

Authors

Gu, W.,Martinez, S.E.,Nguyen, H.,Xu, H.,Herdewijn, P.,de Jonghe, S.,Das, K. (deposition date: 2020-09-27, release date: 2021-01-13, Last modification date: 2024-01-31)

• Primary citation: Gu, W.,Martinez, S.,Nguyen, H.,Xu, H.,Herdewijn, P.,De Jonghe, S.,Das, K.; Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues.; J.Med.Chem., 64:782-796, 2021; PubMed: 33356231; DOI: 10.1021/acs.jmedchem.0c01747

Experimental method

X-RAY DIFFRACTION (2.95 Å)