PDB: 1328 件ウェブページステータス検索Chemie searchBIRD

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4MGZ	Selective activation of Epac1 and Epac2 分子名称: (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... 著者 Rehmann, H. 登録日 2013-08-29 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Selective activation of Epac1 and Epac2 To be Published
4MH0	Selective activation of Epac1 and Epac2 分子名称: (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ... 著者 Rehmann, H. 登録日 2013-08-29 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Selective activation of Epac1 and Epac2 To be Published
4MIT	Crystal structure of E. histolytica RacC bound to the EhPAK4 PBD 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho family GTPase, ... 著者 Bosch, D.E, Siderovski, D.P. 登録日 2013-09-02 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors. Biochemistry, 54, 2015
4NMM	Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor 分子名称: 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION 著者 Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D. 登録日 2013-11-15 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
4NYI	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9612 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
4NYJ	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8522 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
4NYM	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]-L-tryptophanamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5529 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
4O25	Structure of Wild Type Mus musculus Rheb bound to GTP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-16 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4O2L	Structure of Mus musculus Rheb G63A mutant bound to GTP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GTP-binding protein Rheb, ... 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4O2R	Structure of Mus musculus Rheb G63V mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4OBE	Crystal Structure of GDP-bound Human KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-01-07 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
4OJK	Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-11B, cGMP-dependent protein kinase 2 著者 Reger, A.S, Yang, M.P, Guo, E, Kim, C. 登録日 2014-01-21 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.657 Å) 主引用文献 Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions. J.Biol.Chem., 289, 2014
4OL0	Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Tsirkone, V.G, Strelkov, S.V. 登録日 2014-01-23 公開日 2014-04-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. Acta Crystallogr.,Sect.F, 70, 2014
4PHF	Crystal structure of Ypt7 covalently modified with GDP 分子名称: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(trihydrogen diphosphate), ... 著者 Vieweg, S, Wiegandt, D, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015
4PHG	Crystal structure of Ypt7 covalently modified with GTP 分子名称: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(tetrahydrogen triphosphate), ... 著者 Koch, D, Wiegandt, D, Vieweg, S, Hofmann, F, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015
4PHH	Crystal structure of Ypt7 covalently modified with GNP 分子名称: 5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-N-[3-(propanoylamino)propyl]guanosine, CHLORIDE ION, GTP-binding protein YPT7, ... 著者 Wiegandt, D, Vieweg, S, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015
4PZY	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 2-chloro-1-(1H-indol-3-yl)ethanone, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4PZZ	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 1H-benzimidazol-2-ylmethanethiol, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.403 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q01	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.291 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q02	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 3,4-difluorobenzenethiol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q03	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 4-bromobenzenethiol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.201 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
4Q9U	Crystal structure of the Rab5, Rabex-5delta and Rabaptin-5C21 complex 分子名称: Rab GTPase-binding effector protein 1, Rab5 GDP/GTP exchange factor, Ras-related protein Rab-5A 著者 Zhang, Z, Zhang, T, Ding, J. 登録日 2014-05-01 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (4.618 Å) 主引用文献 Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 Elife, 3, 2014
4QL3	Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-06-10 公開日 2015-06-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.041 Å) 主引用文献 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015
4QXA	Crystal structure of the Rab9A-RUTBC2 RBD complex 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-9A, ... 著者 Zhang, Z, Wang, S, Ding, J. 登録日 2014-07-19 公開日 2014-09-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Structure, 22, 2014

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