Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

Summary for 4NYM

DescriptorGTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsgtpase, signaling transduction, raf, ralgds, pi3k, cytosol, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane. Isoform 2: Nucleus P01112 P01112
Total number of polymer chains3
Total molecular weight95153.05
Burns, M.C.,Sun, Q.,Phan, J.,Fesik, S.W. (deposition date: 2013-12-10, release date: 2014-03-12, Last modification date: 2014-03-19)
Primary citation
Burns, M.C.,Sun, Q.,Daniels, R.N.,Camper, D.,Kennedy, J.P.,Phan, J.,Olejniczak, E.T.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111:3401-3406, 2014
PubMed: 24550516 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1315798111
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.213101.5%8.7%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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