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4NYI

Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

Summary for 4NYI
Entry DOI10.2210/pdb4nyi/pdb
DescriptorGTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordsras sos complex, signal transduction, raf, pi3k, poly-petide, cytosol, signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane. Isoform 2: Nucleus: P01112 P01112
Total number of polymer chains3
Total formula weight95281.18
Authors
Burns, M.C.,Sun, Q.,Phan, J.,Fesik, S.W. (deposition date: 2013-12-10, release date: 2014-03-12, Last modification date: 2024-02-28)
Primary citationBurns, M.C.,Sun, Q.,Daniels, R.N.,Camper, D.,Kennedy, J.P.,Phan, J.,Olejniczak, E.T.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Proc.Natl.Acad.Sci.USA, 111:3401-3406, 2014
Cited by
PubMed: 24550516
DOI: 10.1073/pnas.1315798111
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9612 Å)
Structure validation

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