8Q7X
 
 | | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8QDZ
 | |
8QE3
 | |
8QE1
 | |
8QDY
 | |
8OOG
 | |
8OIZ
 | | Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | | 分子名称: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | | 登録日 | 2023-03-23 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.
Chembiochem, 24, 2023
|
|
8OJH
 | | Crystal structure of human CRBN-DDB1 in complex with compound 4 | | 分子名称: | 1,2-ETHANEDIOL, 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione, DNA damage-binding protein 1, ... | | 著者 | Cabry, M.P, Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2023-03-24 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.
Chembiochem, 24, 2023
|
|
8Q1S
 | | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions | | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... | | 著者 | Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. | | 登録日 | 2023-08-01 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | | 主引用文献 | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.
Nat Commun, 15, 2024
|
|
8Q91
 | | Structure of the human 20S U5 snRNP core | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Schneider, S, Galej, W.P. | | 登録日 | 2023-08-19 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
|
|
8SOJ
 | |
8SB6
 | | Structure of human BRD2-BD1 bound to a histone H4 acetyl-methyllysine peptide | | 分子名称: | Bromodomain containing 2, Histone H4 | | 著者 | Connor, L.J, Ekundayo, B.E, Lu-Culligan, W.J, Simon, M.D, Bleichert, F. | | 登録日 | 2023-04-02 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Acetyl-methyllysine marks chromatin at active transcription start sites.
Nature, 622, 2023
|
|
8P1W
 | | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591 | | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine, ... | | 著者 | Thomsen, M, Thieulin-Pardo, G, Neumann, L. | | 登録日 | 2023-05-12 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.
Bioorg.Med.Chem.Lett., 94, 2023
|
|
8P1T
 | | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Z237451470 | | 分子名称: | 1,2-ETHANEDIOL, 6-cyclopropyl-~{N}-(1~{H}-indazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, CHLORIDE ION, ... | | 著者 | Thomsen, M, Thieulin-Pardo, G, Neumann, L. | | 登録日 | 2023-05-12 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.442 Å) | | 主引用文献 | Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.
Bioorg.Med.Chem.Lett., 94, 2023
|
|
8P4H
 | | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound IDEAYA cmpd A | | 分子名称: | 7-chloranyl-4-[(3R)-3-fluoranylpyrrolidin-1-yl]-1-phenyl-quinazolin-2-one, CHLORIDE ION, GLYCEROL, ... | | 著者 | Thomsen, M, Thieulin-Pardo, G, Neumann, L. | | 登録日 | 2023-05-21 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.
Bioorg.Med.Chem.Lett., 94, 2023
|
|
8QVW
 | | Cryo-EM structure of the peptide binding domain of human SRP68/72 | | 分子名称: | Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72 | | 著者 | Zhong, Y, Feng, J, Koh, A.F, Kotecha, A, Greber, B.J, Ataide, S.F. | | 登録日 | 2023-10-18 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of nPBD of human SRP68/72
To Be Published
|
|
8Q34
 | | Crystal structure of the first bromodomain of human BRD4 in complex with the ligand ZZ001229a | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(1~{H}-imidazo[4,5-b]pyridin-2-ylmethyl)-3-(3-methyl-1,2-diazirin-3-yl)propanamide | | 著者 | MacLean, E.M, Gao, Q, Williams, E, Balcomb, B.H, von Delft, F, Bajusz, D, Keeley, A, Abranyi-Balogh, P, Koekemoer, L, Keseru, G.M. | | 登録日 | 2023-08-03 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Mapping protein binding sites by photoreactive fragment pharmacophores
Res Sq, 2023
|
|
8Q5H
 | | Human KMN network (outer kinetochore) | | 分子名称: | Kinetochore protein Spc24, Kinetochore protein Spc25, Kinetochore scaffold 1, ... | | 著者 | Raisch, T, Polley, S, Vetter, I, Musacchio, A, Raunser, S. | | 登録日 | 2023-08-09 | | 公開日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN network
To Be Published
|
|
6Z0O
 | | Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein | | 分子名称: | Affimer-NP, Nucleocapsid | | 著者 | Alvarez-Rodriguez, B, Tiede, C, Trinh, C, Tomlinson, D, Edwards, T.A, Barr, J.N. | | 登録日 | 2020-05-10 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5974 Å) | | 主引用文献 | Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Plos Negl Trop Dis, 14, 2020
|
|
6DL7
 | | Human mitochondrial ClpP in complex with ONC201 (TIC10) | | 分子名称: | 7-benzyl-4-[(2-methylphenyl)methyl]-6,7,8,9-tetrahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | | 著者 | Halgas, O, Zarabi, S.F, Schimmer, A, Pai, E.F. | | 登録日 | 2018-05-31 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Cancer Cell, 35, 2019
|
|
6M0U
 | |
4NIQ
 | | Crystal Structure of Vps4 MIT-Vfa1 MIM2 | | 分子名称: | VPS4-associated protein 1, Vacuolar protein sorting-associated protein 4 | | 著者 | Vild, C.J, Xu, Z. | | 登録日 | 2013-11-06 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Vfa1 Binds to the N-terminal Microtubule-interacting and Trafficking (MIT) Domain of Vps4 and Stimulates Its ATPase Activity.
J.Biol.Chem., 289, 2014
|
|
5ZBU
 | |
5YWR
 | | Crystal Structure of RING E3 ligase ZNRF1 in complex with Ube2N (Ubc13) | | 分子名称: | E3 ubiquitin-protein ligase ZNRF1, FORMIC ACID, TRIETHYLENE GLYCOL, ... | | 著者 | Behera, A.P, Naskar, P, Datta, A.B. | | 登録日 | 2017-11-30 | | 公開日 | 2018-06-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
Biochem. J., 475, 2018
|
|
5ZC4
 | |
