8OOG

Crystal structure of human MAT2a with S-Adenosylmethionine and a fragment bound in a novel pocket

Summary for 8OOG

Entry DOI	10.2210/pdb8oog/pdb
Descriptor	S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 6-oxidanyl-1,3-benzoxathiol-2-one, ... (5 entities in total)
Functional Keywords	methionine adenosyltransferase, s-adenosylmethionine synthetase, fragment screen, allosteric binder, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	44658.70
Authors	Schimpl, M. (deposition date: 2023-04-05, release date: 2023-07-12)
Primary citation	La Sala, G.,Pfleger, C.,Kack, H.,Wissler, L.,Nevin, P.,Bohm, K.,Janet, J.P.,Schimpl, M.,Stubbs, C.J.,De Vivo, M.,Tyrchan, C.,Hogner, A.,Gohlke, H.,Frolov, A.I. Combining structural and coevolution information to unveil allosteric sites. Chem Sci, 14:7057-7067, 2023 Cited by PubMed: 37389247 DOI: 10.1039/d2sc06272k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.384 Å)

Structure validation