8Q34

Crystal structure of the first bromodomain of human BRD4 in complex with the ligand ZZ001229a

Summary for 8Q34

• Entry DOI: 10.2210/pdb8q34/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ~{N}-(1~{H}-imidazo[4,5-b]pyridin-2-ylmethyl)-3-(3-methyl-1,2-diazirin-3-yl)propanamide, ... (4 entities in total)
• Functional Keywords: ligand complex, bromodomain, covalent, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 63052.41

Authors

MacLean, E.M.,Gao, Q.,Williams, E.,Balcomb, B.H.,von Delft, F.,Bajusz, D.,Keeley, A.,Abranyi-Balogh, P.,Koekemoer, L.,Keseru, G.M. (deposition date: 2023-08-03, release date: 2024-02-07)

• Primary citation: Keseru, G.M.; Mapping protein binding sites by photoreactive fragment pharmacophores; Res Sq, 2023; DOI: 10.21203/rs.3.rs-3379575/v1

Experimental method

X-RAY DIFFRACTION (1.48 Å)