8Q34
Crystal structure of the first bromodomain of human BRD4 in complex with the ligand ZZ001229a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Bromodomain-containing protein 4 | polymer | 130 | 15442.8 | 4 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
| 2 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | A, B, C, D | ~{N}-(1~{H}-imidazo[4,5-b]pyridin-2-ylmethyl)-3-(3-methyl-1,2-diazirin-3-yl)propanamide | non-polymer | 258.3 | 4 | Chemie (IX4) | |||
| 4 | water | water | 18.0 | 804 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 44 - 171 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61771.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1281.4 | |
| All* | Total formula weight | 63052.4 |
