8OJH

Crystal structure of human CRBN-DDB1 in complex with compound 4

Summary for 8OJH

• Entry DOI: 10.2210/pdb8ojh/pdb
• Descriptor: DNA damage-binding protein 1, Protein cereblon, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: e3-ligase, degradation, glue, protac, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 175811.61

Authors

Cabry, M.P.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2023-03-24, release date: 2023-07-19, Last modification date: 2023-12-13)

• Primary citation: Bouguenina, H.,Scarpino, A.,O'Hanlon, J.A.,Warne, J.,Wang, H.Z.,Wah Hak, L.C.,Sadok, A.,McAndrew, P.C.,Stubbs, M.,Pierrat, O.A.,Hahner, T.,Cabry, M.P.,Le Bihan, Y.V.,Mitsopoulos, C.,Sialana, F.J.,Roumeliotis, T.I.,Burke, R.,van Montfort, R.L.M.,Choudhari, J.,Chopra, R.,Caldwell, J.J.,Collins, I.; A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.; Chembiochem, 24:e202300351-e202300351, 2023; PubMed: 37418539; DOI: 10.1002/cbic.202300351

Experimental method

X-RAY DIFFRACTION (2.72 Å)