8OJH

Crystal structure of human CRBN-DDB1 in complex with compound 4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	1148	128139.6	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B (B)	Protein cereblon	polymer	407	46744.7	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
3	C, D, E, F, G... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
4	J (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	K (B)	4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione	non-polymer		303.3	1	Chemie (VP9)
6	N, O (A, B)	water	water		18.0	345	Chemie (HOH)

Sequence modifications

A: 1 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Trp 1141	-	expression tag
Ser 1142	-	expression tag
His 1143	-	expression tag
Pro 1144	-	expression tag
Gln 1145	-	expression tag
Phe 1146	-	expression tag
Glu 1147	-	expression tag
Lys 1148	-	expression tag

B: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 36	-	expression tag
Pro 37	-	expression tag
His 38	-	expression tag
Met 39	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	174884.3
Non-Polymers*	Number of molecules	11
	Total formula weight	927.3
All*	Total formula weight	175811.6

*Water molecules are not included.