8OJH
Crystal structure of human CRBN-DDB1 in complex with compound 4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA damage-binding protein 1 | polymer | 1148 | 128139.6 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
2 | B | Protein cereblon | polymer | 407 | 46744.7 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (human) | |
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
4 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
5 | B | 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione | non-polymer | 303.3 | 1 | Chemie (VP9) | |||
6 | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A: 1 - 1140 (UniProt: Q16531)
B: 40 - 442 (UniProt: Q96SW2)
PDB | External Database | Details |
---|---|---|
Trp 1141 | - | expression tag |
Ser 1142 | - | expression tag |
His 1143 | - | expression tag |
Pro 1144 | - | expression tag |
Gln 1145 | - | expression tag |
Phe 1146 | - | expression tag |
Glu 1147 | - | expression tag |
Lys 1148 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 36 | - | expression tag |
Pro 37 | - | expression tag |
His 38 | - | expression tag |
Met 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 174884.3 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 927.3 | |
All* | Total formula weight | 175811.6 |