8P1W
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591
This is a non-PDB format compatible entry.
Summary for 8P1W
| Entry DOI | 10.2210/pdb8p1w/pdb |
| Descriptor | S-adenosylmethionine synthase isoform type-2, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALPHA-AMINOBUTYRIC ACID, ... (7 entities in total) |
| Functional Keywords | methionine adenosyltransferase, s-adenosylmethionine synthase isoform 2 type-2, sam, allosteric inhibitor, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 46857.20 |
| Authors | Thomsen, M.,Thieulin-Pardo, G.,Neumann, L. (deposition date: 2023-05-12, release date: 2023-08-30, Last modification date: 2023-11-15) |
| Primary citation | Kalliokoski, T.,Kettunen, H.,Kumpulainen, E.,Kettunen, E.,Thieulin-Pardo, G.,Neumann, L.,Thomsen, M.,Paul, R.,Malyutina, A.,Georgiadou, M. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94:129450-129450, 2023 Cited by PubMed: 37591318DOI: 10.1016/j.bmcl.2023.129450 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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