8P1W
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | AAA | S-adenosylmethionine synthase isoform type-2 | polymer | 412 | 45703.7 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) In PDB | Homo sapiens (human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
2 | AAA | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) | |||
3 | AAA | ALPHA-AMINOBUTYRIC ACID | non-polymer | 103.1 | 1 | Chemie (ABA) | |||
4 | AAA | 8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine | non-polymer | 336.4 | 1 | Chemie (WK5) | |||
5 | AAA | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
6 | AAA | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
7 | water | water | 18.0 | 406 | Chemie (HOH) |
Sequence modifications
AAA: 2 - 395 (UniProt: P31153)
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
Ala -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
Ser -8 | - | expression tag |
Ser -7 | - | expression tag |
Gly -6 | - | expression tag |
Glu -5 | - | expression tag |
Asn -4 | - | expression tag |
Leu -3 | - | expression tag |
Tyr -2 | - | expression tag |
Phe -1 | - | expression tag |
Gln 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45703.7 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1153.5 | |
All* | Total formula weight | 46857.2 |