8P1W
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with allosteric compound STL232591
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | S-adenosylmethionine synthase isoform type-2 | polymer | 412 | 45703.7 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | B (AAA) | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) PubChem (149) PubChem (25322898) PubChem (40467850) PubChem (44264468) PubChem (46874793) PubChem (51397471) PubChem (57104771) PubChem (58108938) PubChem (58682801) PubChem (439176) PubChem (59099797) PubChem (51397472) PubChem (688097) PubChem (99302) PubChem (453683) PubChem (91614589) PubChem (98100246) PubChem (6541356) PubChem (124300729) PubChem (124300795) PubChem (13101165) PubChem (13101166) PubChem (134694842) PubChem (138107656) PubChem (164077596) | |||
| 3 | C (AAA) | ALPHA-AMINOBUTYRIC ACID | non-polymer | 103.1 | 1 | Chemie (ABA) | |||
| 4 | D (AAA) | 8-methoxy-1-(4-methoxyphenyl)-3-methyl-2-oxidanyl-[1]benzofuro[3,2-c]pyridine | non-polymer | 336.4 | 1 | Chemie (WK5) | |||
| 5 | E, F, G (AAA) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 6 | H, I, J, K, L (AAA) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | M (AAA) | water | water | 18.0 | 406 | Chemie (HOH) |
Sequence modifications
AAA: 2 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| Ala -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45703.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1153.5 | |
| All* | Total formula weight | 46857.2 |
