8P4H

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound IDEAYA cmpd A

Summary for 8P4H

Entry DOI	10.2210/pdb8p4h/pdb
Descriptor	S-adenosylmethionine synthase isoform type-2, 7-chloranyl-4-[(3R)-3-fluoranylpyrrolidin-1-yl]-1-phenyl-quinazolin-2-one, GLYCEROL, ... (7 entities in total)
Functional Keywords	methionine adenosyltransferase, sam, allosteric inhibitor, transferase, transferase-inhibitor complex
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	185814.90
Authors	Thomsen, M.,Thieulin-Pardo, G.,Neumann, L. (deposition date: 2023-05-21, release date: 2023-08-30, Last modification date: 2023-11-15)
Primary citation	Kalliokoski, T.,Kettunen, H.,Kumpulainen, E.,Kettunen, E.,Thieulin-Pardo, G.,Neumann, L.,Thomsen, M.,Paul, R.,Malyutina, A.,Georgiadou, M. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg.Med.Chem.Lett., 94:129450-129450, 2023 Cited by PubMed: 37591318 DOI: 10.1016/j.bmcl.2023.129450 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation