PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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5FI4	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Elling, R.A, Knapp, M.S, Han, W, Daniel, L.M, Xy, Y, Burger, M.T, Ni, Z, Smith, A, Lan, J, Williams, T, Verhagen, J, Huh, K, Merritt, H, Chan, J, Kaufman, S, Voliva, C.F, Pecchi, S. 登録日 2015-12-22 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg.Med.Chem.Lett., 26, 2016
4E68	Unphosphorylated STAT3B core protein binding to dsDNA 分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 著者 Collie, G.W, Parkinson, G.N, Shah, R. 登録日 2012-03-15 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.585 Å) 主引用文献 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Febs Lett., 587, 2013
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-27 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4FL3	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4GL9	Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain 分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... 著者 Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. 登録日 2012-08-14 公開日 2013-03-06 最終更新日 2018-06-13 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20, 2013
4FL2	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4H34	Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-13 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation To be Published
4H1O	Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation 分子名称: 1,2-ETHANEDIOL, Tyrosine-protein phosphatase non-receptor type 11 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-11 公開日 2013-09-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation To be Published
4GWF	Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-03 公開日 2013-09-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation TO BE PUBLISHED
4E93	Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 分子名称: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps 著者 Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-03-20 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
2PTK	CHICKEN SRC TYROSINE KINASE 分子名称: TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC 著者 Williams, J.C, Wierenga, R. 登録日 1997-06-17 公開日 1997-12-24 最終更新日 2018-04-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J.Mol.Biol., 274, 1997
2OZO	Autoinhibited intact human ZAP-70 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase ZAP-70 著者 Deindl, S, Kadlecek, T.A, Brdicka, T, Cao, X, Weiss, A, Kuriyan, J. 登録日 2007-02-26 公開日 2007-05-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70. Cell(Cambridge,Mass.), 129, 2007
2SHP	TYROSINE PHOSPHATASE SHP-2 分子名称: DODECANE-TRIMETHYLAMINE, SHP-2 著者 Hof, P, Pluskey, S, Dhe-Paganon, S, Eck, M.J, Shoelson, S.E. 登録日 1997-12-01 公開日 1999-02-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2. Cell(Cambridge,Mass.), 92, 1998
2SRC	CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC 著者 Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C. 登録日 1998-12-29 公開日 1999-07-22 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol.Cell, 3, 1999
2OQ1	Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide 分子名称: LEAD (II) ION, T-cell surface glycoprotein CD3 zeta chain, Tyrosine-protein kinase ZAP-70 著者 Hatada, M.H, Laird, E.R, Green, J, Morgenstern, J, Ram, M.K. 登録日 2007-01-30 公開日 2007-03-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for the interaction of ZAP-70 with the T-cell receptor Nature, 377, 1995
2RD0	Structure of a human p110alpha/p85alpha complex 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Huang, C, Gabelli, S.B, Amzel, L.M. 登録日 2007-09-20 公開日 2007-12-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science, 318, 2007
3VS1	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.464 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS4	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS0	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide 分子名称: CALCIUM ION, CHLORIDE ION, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide, ... 著者 Kuratani, M, Honda, K, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.934 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRZ	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.218 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRY	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane 分子名称: 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.481 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS7	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 分子名称: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS6	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate 分子名称: CALCIUM ION, CHLORIDE ION, Tyrosine-protein kinase HCK, ... 著者 Kuratani, M, Honda, K, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.373 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS3	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomaebchi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS5	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, Tyrosine-protein kinase HCK 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.851 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013

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