PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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5XGH	Crystal structure of PI3K complex with an inhibitor 分子名称: 3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... 著者 Song, K, Yang, X, Zhao, Y, Jian, Z. 登録日 2017-04-13 公開日 2018-04-25 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound. Sci Rep, 7, 2017
5FI4	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Elling, R.A, Knapp, M.S, Han, W, Daniel, L.M, Xy, Y, Burger, M.T, Ni, Z, Smith, A, Lan, J, Williams, T, Verhagen, J, Huh, K, Merritt, H, Chan, J, Kaufman, S, Voliva, C.F, Pecchi, S. 登録日 2015-12-22 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg.Med.Chem.Lett., 26, 2016
5X7B	Crystal structure of SHP2_SH2-CagA EPIYA_C peptide complex 分子名称: CagA, Tyrosine-protein phosphatase non-receptor type 11 著者 Senda, M, Senda, T. 登録日 2017-02-24 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
4E93	Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 分子名称: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps 著者 Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-03-20 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. 登録日 2012-01-27 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
1RQQ	Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS 分子名称: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ... 著者 Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. 登録日 2003-12-06 公開日 2003-12-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
4H34	Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-13 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation To be Published
4FL3	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4GWF	Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-03 公開日 2013-09-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation TO BE PUBLISHED
4H1O	Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation 分子名称: 1,2-ETHANEDIOL, Tyrosine-protein phosphatase non-receptor type 11 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battaile, K, Chirgadze, N.Y. 登録日 2012-09-11 公開日 2013-09-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with D61G mutation To be Published
4FL2	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4E68	Unphosphorylated STAT3B core protein binding to dsDNA 分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 著者 Collie, G.W, Parkinson, G.N, Shah, R. 登録日 2012-03-15 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.585 Å) 主引用文献 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Febs Lett., 587, 2013
1TCE	SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE 分子名称: PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC 著者 Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W. 登録日 1996-03-27 公開日 1997-05-15 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. Proc.Natl.Acad.Sci.USA, 92, 1995
4GL9	Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain 分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... 著者 Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. 登録日 2012-08-14 公開日 2013-03-06 最終更新日 2018-06-13 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20, 2013
1UUS	Structure of an activated Dictyostelium STAT in its DNA-unbound form 分子名称: STAT PROTEIN 著者 Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W. 登録日 2004-01-09 公開日 2004-03-26 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form Mol.Cell, 13, 2004
1JU5	Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy 分子名称: Abl, Crk 著者 Donaldson, L.W, Pawson, T, Kay, L.E, Forman-Kay, J.D. 登録日 2001-08-23 公開日 2002-11-06 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide Proc.Natl.Acad.Sci.USA, 99, 2002
1K9A	Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution 分子名称: Carboxyl-terminal Src kinase 著者 Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. 登録日 2001-10-28 公開日 2002-03-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the carboxyl-terminal Src kinase, Csk. J.Biol.Chem., 277, 2002
1KSW	Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP 分子名称: N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. 登録日 2002-01-14 公開日 2002-02-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
3VRZ	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.218 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS7	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 分子名称: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS1	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.464 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS4	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS0	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide 分子名称: CALCIUM ION, CHLORIDE ION, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide, ... 著者 Kuratani, M, Honda, K, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.934 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS3	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomaebchi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS6	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate 分子名称: CALCIUM ION, CHLORIDE ION, Tyrosine-protein kinase HCK, ... 著者 Kuratani, M, Honda, K, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.373 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013

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