Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain

Summary for 4GL9

DescriptorTyrosine-protein kinase, Interleukin-6 receptor subunit beta, Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3, ... (5 entities in total)
Functional Keywordskinase inhibitor receptor cytokine signalling, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (Mouse)
Total number of polymer chains12
Total molecular weight210768.17
Kershaw, N.J.,Murphy, J.M.,Laktyushin, A.,Nicola, N.A.,Babon, J.J. (deposition date: 2012-08-14, release date: 2013-03-06, Last modification date: 2018-06-13)
Primary citation
Kershaw, N.J.,Murphy, J.M.,Liau, N.P.,Varghese, L.N.,Laktyushin, A.,Whitlock, E.L.,Lucet, I.S.,Nicola, N.A.,Babon, J.J.
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Nat.Struct.Mol.Biol., 20:469-476, 2013
PubMed: 23454976 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2519
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2929 0.1% 2.0% 14.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25