4GL9

Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IZA A 2001

Chain	Residue
A	LEU855
A	ALA880
A	MET929
A	GLU930
A	LEU932
A	PRO933
A	GLY935

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IZA B 1201

Chain	Residue
B	ALA880
B	MET929
B	GLU930
B	TYR931
B	LEU932
B	GLY935
B	LEU983
B	ASP994
B	LEU855
B	VAL863

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 1202

Chain	Residue
B	GLU985
B	ARG989
C	TYR934
C	HIS944
C	ARG947

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IZA C 1201

Chain	Residue
C	LEU855
C	LYS857
C	GLY858
C	ALA880
C	MET929
C	GLU930
C	LEU932
C	ARG980
C	ASP994

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IZA D 1201

Chain	Residue
D	LEU855
D	LYS857
D	GLY858
D	VAL863
D	ALA880
D	MET929
D	GLU930
D	TYR931
D	LEU932
D	GLY935

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK

Chain	Residue	Details
A	LEU855-LYS883

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV

Chain	Residue	Details
A	TYR972-VAL984

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP976
B	ASP976
C	ASP976
D	ASP976

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU855
A	LYS882
B	LEU855
B	LYS882
C	LEU855
C	LYS882
D	LEU855
D	LYS882

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20304997

Chain	Residue	Details
A	TYR868
C	TYR966
C	TYR972
C	PTR1008
D	TYR868
D	TYR966
D	TYR972
D	PTR1008
A	TYR966
A	TYR972
A	PTR1008
B	TYR868
B	TYR966
B	TYR972
B	PTR1008
C	TYR868

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:9473212

Chain	Residue	Details
A	PTR1007
B	PTR1007
C	PTR1007
D	PTR1007

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