4GL9
Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, I (A, B, C, D) | Tyrosine-protein kinase | polymer | 297 | 35111.9 | 4 | UniProt (G5E852) Pfam (PF07714) UniProt (by SIFTS) (Q62120) | Mus musculus (Mouse) | |
| 2 | C, E, F, H (I, K, J, L) | Interleukin-6 receptor subunit beta | polymer | 15 | 1605.6 | 4 | UniProt (Q00560) | Mus musculus | IL-6RB,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha |
| 3 | G, J, K, L (E, F, G, H) | Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3 | polymer | 143 | 15641.5 | 4 | UniProt (O35718) Pfam (PF00017) | Mus musculus (Mouse) | SOCS-3,Cytokine-inducible SH2 protein 3,CIS-3,Protein EF-10 |
| 4 | M, N, P, Q (A, B, C, D) | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE | non-polymer | 309.3 | 4 | Chemie (IZA) | |||
| 5 | O (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence modifications
I, K, J, L: 750 - 764 (UniProt: Q00560)
E, F, G, H: 38 - 128 (UniProt: O35718)
E, F, G, H: 159 - 162 (PDB: 4GL9)
| PDB | External Database | Details |
|---|---|---|
| Glu 756 | Gln 756 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gln 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Ala 19 | - | expression tag |
| His 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Lys 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Glu 30 | - | expression tag |
| Tyr 31 | - | expression tag |
| Gln 32 | - | expression tag |
| Leu 33 | - | expression tag |
| Val 34 | - | expression tag |
| Val 35 | - | expression tag |
| Asn 36 | - | expression tag |
| Ala 37 | - | expression tag |
| Gly 132 | - | linker |
| Ser 133 | - | linker |
| Gly 134 | - | linker |
| Ser 135 | - | linker |
| Gly 136 | - | linker |
| Ser 137 | - | linker |
| Gly 138 | - | linker |
| Ser 139 | - | linker |
| Arg 140 | - | linker |
| Ala 141 | - | linker |
| Tyr 142 | - | linker |
| Tyr 143 | - | linker |
| Ile 144 | - | linker |
| Tyr 145 | - | linker |
| Ser 146 | - | linker |
| Gly 147 | - | linker |
| Gly 148 | - | linker |
| Glu 149 | - | linker |
| Lys 150 | - | linker |
| Ile 151 | - | linker |
| Pro 152 | - | linker |
| Leu 153 | - | linker |
| Val 154 | - | linker |
| Leu 155 | - | linker |
| Ser 156 | - | linker |
| Arg 157 | - | linker |
| Pro 158 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 209435.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1332.3 | |
| All* | Total formula weight | 210768.2 |
