5XGH

Crystal structure of PI3K complex with an inhibitor

Summary for 5XGH

• Entry DOI: 10.2210/pdb5xgh/pdb
• Related: 5XGI 5XGJ
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, ... (6 entities in total)
• Functional Keywords: pi3k, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 156203.76

Authors

Song, K.,Yang, X.,Zhao, Y.,Jian, Z. (deposition date: 2017-04-13, release date: 2018-04-25, Last modification date: 2024-03-27)

• Primary citation: Yang, X.,Zhang, X.,Huang, M.,Song, K.,Li, X.,Huang, M.,Meng, L.,Zhang, J.; New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound.; Sci Rep, 7:14572-14572, 2017; PubMed: 29109464; DOI: 10.1038/s41598-017-15260-5

Experimental method

X-RAY DIFFRACTION (2.97 Å)