4GWF

Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation

Summary for 4GWF

• Entry DOI: 10.2210/pdb4gwf/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 1,2-ETHANEDIOL, GLYCEROL, ... (6 entities in total)
• Functional Keywords: alpha/beta proteins, sh2 domain, phosphatase domain, tyrosine phosphatase shp-2, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q06124
• Total number of polymer chains: 2
• Total formula weight: 130144.63

Authors

Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battaile, K.,Chirgadze, N.Y. (deposition date: 2012-09-03, release date: 2013-09-04, Last modification date: 2023-09-13)

• Primary citation: Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battaile, K.,Chirgadze, N.Y.; Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.1 Å)