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4GWF

Crystal structure of the tyrosine phosphatase SHP-2 with Y279C mutation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0001784molecular_functionphosphotyrosine residue binding
A0004721molecular_functionphosphoprotein phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
A0005158molecular_functioninsulin receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006470biological_processprotein dephosphorylation
A0006629biological_processlipid metabolic process
A0006641biological_processtriglyceride metabolic process
A0007165biological_processsignal transduction
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0007409biological_processaxonogenesis
A0007420biological_processbrain development
A0007507biological_processheart development
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009755biological_processhormone-mediated signaling pathway
A0009967biological_processpositive regulation of signal transduction
A0016311biological_processdephosphorylation
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0019221biological_processcytokine-mediated signaling pathway
A0019901molecular_functionprotein kinase binding
A0021697biological_processcerebellar cortex formation
A0030159molecular_functionsignaling receptor complex adaptor activity
A0030220biological_processplatelet formation
A0030971molecular_functionreceptor tyrosine kinase binding
A0031295biological_processT cell costimulation
A0032331biological_processnegative regulation of chondrocyte differentiation
A0032480biological_processnegative regulation of type I interferon production
A0032528biological_processmicrovillus organization
A0032728biological_processpositive regulation of interferon-beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032991cellular_componentprotein-containing complex
A0033628biological_processregulation of cell adhesion mediated by integrin
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0035264biological_processmulticellular organism growth
A0035265biological_processorgan growth
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0035855biological_processmegakaryocyte development
A0036302biological_processatrioventricular canal development
A0038127biological_processERBB signaling pathway
A0042445biological_processhormone metabolic process
A0042593biological_processglucose homeostasis
A0043254biological_processregulation of protein-containing complex assembly
A0043408biological_processregulation of MAPK cascade
A0045296molecular_functioncadherin binding
A0045778biological_processpositive regulation of ossification
A0045931biological_processpositive regulation of mitotic cell cycle
A0046326biological_processpositive regulation of glucose import
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046676biological_processnegative regulation of insulin secretion
A0046825biological_processregulation of protein export from nucleus
A0046887biological_processpositive regulation of hormone secretion
A0046888biological_processnegative regulation of hormone secretion
A0048008biological_processplatelet-derived growth factor receptor signaling pathway
A0048011biological_processneurotrophin TRK receptor signaling pathway
A0048013biological_processephrin receptor signaling pathway
A0048609biological_processmulticellular organismal reproductive process
A0048806biological_processgenitalia development
A0048839biological_processinner ear development
A0048873biological_processhomeostasis of number of cells within a tissue
A0050660molecular_functionflavin adenine dinucleotide binding
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050839molecular_functioncell adhesion molecule binding
A0051428molecular_functionpeptide hormone receptor binding
A0051463biological_processnegative regulation of cortisol secretion
A0060020biological_processBergmann glial cell differentiation
A0060090molecular_functionmolecular adaptor activity
A0060125biological_processnegative regulation of growth hormone secretion
A0060325biological_processface morphogenesis
A0060338biological_processregulation of type I interferon-mediated signaling pathway
A0061582biological_processintestinal epithelial cell migration
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071364biological_processcellular response to epidermal growth factor stimulus
A1990782molecular_functionprotein tyrosine kinase binding
B0000077biological_processDNA damage checkpoint signaling
B0001784molecular_functionphosphotyrosine residue binding
B0004721molecular_functionphosphoprotein phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0004726molecular_functionnon-membrane spanning protein tyrosine phosphatase activity
B0005158molecular_functioninsulin receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006470biological_processprotein dephosphorylation
B0006629biological_processlipid metabolic process
B0006641biological_processtriglyceride metabolic process
B0007165biological_processsignal transduction
B0007173biological_processepidermal growth factor receptor signaling pathway
B0007229biological_processintegrin-mediated signaling pathway
B0007409biological_processaxonogenesis
B0007420biological_processbrain development
B0007507biological_processheart development
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009755biological_processhormone-mediated signaling pathway
B0009967biological_processpositive regulation of signal transduction
B0016311biological_processdephosphorylation
B0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
B0019221biological_processcytokine-mediated signaling pathway
B0019901molecular_functionprotein kinase binding
B0021697biological_processcerebellar cortex formation
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030220biological_processplatelet formation
B0030971molecular_functionreceptor tyrosine kinase binding
B0031295biological_processT cell costimulation
B0032331biological_processnegative regulation of chondrocyte differentiation
B0032480biological_processnegative regulation of type I interferon production
B0032528biological_processmicrovillus organization
B0032728biological_processpositive regulation of interferon-beta production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032991cellular_componentprotein-containing complex
B0033628biological_processregulation of cell adhesion mediated by integrin
B0033629biological_processnegative regulation of cell adhesion mediated by integrin
B0035264biological_processmulticellular organism growth
B0035265biological_processorgan growth
B0035335biological_processpeptidyl-tyrosine dephosphorylation
B0035855biological_processmegakaryocyte development
B0036302biological_processatrioventricular canal development
B0038127biological_processERBB signaling pathway
B0042445biological_processhormone metabolic process
B0042593biological_processglucose homeostasis
B0043254biological_processregulation of protein-containing complex assembly
B0043408biological_processregulation of MAPK cascade
B0045296molecular_functioncadherin binding
B0045778biological_processpositive regulation of ossification
B0045931biological_processpositive regulation of mitotic cell cycle
B0046326biological_processpositive regulation of glucose import
B0046628biological_processpositive regulation of insulin receptor signaling pathway
B0046676biological_processnegative regulation of insulin secretion
B0046825biological_processregulation of protein export from nucleus
B0046887biological_processpositive regulation of hormone secretion
B0046888biological_processnegative regulation of hormone secretion
B0048008biological_processplatelet-derived growth factor receptor signaling pathway
B0048011biological_processneurotrophin TRK receptor signaling pathway
B0048013biological_processephrin receptor signaling pathway
B0048609biological_processmulticellular organismal reproductive process
B0048806biological_processgenitalia development
B0048839biological_processinner ear development
B0048873biological_processhomeostasis of number of cells within a tissue
B0050660molecular_functionflavin adenine dinucleotide binding
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050839molecular_functioncell adhesion molecule binding
B0051428molecular_functionpeptide hormone receptor binding
B0051463biological_processnegative regulation of cortisol secretion
B0060020biological_processBergmann glial cell differentiation
B0060090molecular_functionmolecular adaptor activity
B0060125biological_processnegative regulation of growth hormone secretion
B0060325biological_processface morphogenesis
B0060338biological_processregulation of type I interferon-mediated signaling pathway
B0061582biological_processintestinal epithelial cell migration
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071364biological_processcellular response to epidermal growth factor stimulus
B1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 601
ChainResidue
AARG4
APHE7
APHE41
ATYR63
AGLU252
AGLN255

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 603
ChainResidue
AASN410
ATHR411
AGLU412

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 604
ChainResidue
AHIS287
AGLU313
ASER499

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 605
ChainResidue
AGLY295
AARG343
AVAL382

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 606
ChainResidue
AVAL388
AGLU400

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG A 607
ChainResidue
ATYR396
ALEU398
ATYR418
AGLU441

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG A 608
ChainResidue
AHIS394
ATYR396
AASP437

site_idAC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PGE A 609
ChainResidue
AARG111
ATHR219
AGLU250
ATHR253
ALEU254
AGLN257
APRO491
ALYS492
AGLN495
AHOH744

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 601
ChainResidue
BARG4
BPHE7
BPHE41
BTYR63
BGLU252
BGLN255
BEDO609

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 602
ChainResidue
BPRO312
BLYS325
BTYR327
BILE474
BASP477

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 603
ChainResidue
BASP437
BHIS520
BTHR524
BEDO604

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 604
ChainResidue
BTYR521
BLEU525
BARG528
BEDO603

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 605
ChainResidue
BARG351
BTHR414
BTRP416
BILE449

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 606
ChainResidue
BTRP6
BALA75
BVAL78
BGLN79
BCYS259

site_idBC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE EDO B 607
ChainResidue
BGLY409

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 608
ChainResidue
BSER391
BGLU400
BTRP416
BHOH737
BHOH786

site_idBC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 609
ChainResidue
BPHE41
BTYR63
BPHE251
BGLN506
BTHR507
BGLU508
BEDO601
BHOH824

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 610
ChainResidue
BGLY295
BASP296
BVAL382
BHOH827

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG
ChainResidueDetails
AVAL457-GLY467

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate
ChainResidueDetails
ACYS459
BCYS459

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP425
ACYS459
AGLN506
BASP425
BCYS459
BGLN506

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ATHR2
BTHR2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR62
BTYR62

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35235
ChainResidueDetails
ATYR66
BTYR66

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by PDGFR => ECO:0000269|PubMed:34310951
ChainResidueDetails

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PDB entries from 2024-07-17

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