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5ZKQ
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Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ...
著者Cao, C, Zhao, Q, Zhang, X.C, Wu, B.
登録日2018-03-25
公開日2018-06-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
6ME3
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BU of 6me3 by Molmil
XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin
分子名称: DI(HYDROXYETHYL)ETHER, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, OLEIC ACID, ...
著者Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569, 2019
5TVN
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Crystal structure of the LSD-bound 5-HT2B receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ...
著者Wacker, D, Wang, S, McCorvy, J.D, Betz, R.M, Venkatakrishnan, A.J, Levit, A, Lansu, K, Schools, Z.L, Che, T, Nichols, D.E, Shoichet, B.K, Dror, R.O, Roth, B.L.
登録日2016-11-09
公開日2017-02-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Cell, 168, 2017
7Y15
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Cryo-EM structure of apo-state MrgD-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7F1Q
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BU of 7f1q by Molmil
Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi
分子名称: C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B.
登録日2021-06-09
公開日2021-07-14
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
7F9Y
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ghrelin-bound ghrelin receptor in complex with Gq
分子名称: CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ...
著者Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y.
登録日2021-07-05
公開日2021-08-18
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor.
Nat Commun, 12, 2021
6C1Q
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Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727
分子名称: 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, PMX53, Soluble cytochrome b562, ...
著者Liu, H, Wang, L, Wei, Z, Zhang, C.
登録日2018-01-05
公開日2018-05-30
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Orthosteric and allosteric action of the C5a receptor antagonists.
Nat. Struct. Mol. Biol., 25, 2018
7EZM
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BU of 7ezm by Molmil
Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex
分子名称: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y.
登録日2021-06-01
公開日2021-08-25
最終更新日2022-06-29
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Nat.Chem.Biol., 17, 2021
7F4F
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Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16
分子名称: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
登録日2021-06-18
公開日2021-09-08
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
7F2O
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Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
分子名称: ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG, B2 bradykinin receptor, G subunit q (Gi1-Gq chimeric), ...
著者Yin, Y, Jiang, Y.
登録日2021-06-11
公開日2021-10-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
Nat.Struct.Mol.Biol., 28, 2021
7F6H
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BU of 7f6h by Molmil
Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin
分子名称: Bradykinin, Bradykinin receptor BK2R, CHOLESTEROL, ...
著者Shen, J, Zhang, D, Fu, Y, Chen, A, Zhang, H.
登録日2021-06-25
公開日2022-01-05
最終更新日2023-01-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structures of human bradykinin receptor-G q proteins complexes.
Nat Commun, 13, 2022
4DJH
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BU of 4djh by Molmil
Structure of the human kappa opioid receptor in complex with JDTic
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CITRIC ACID, ...
著者Wu, H, Wacker, D, Katritch, V, Mileni, M, Han, G.W, Vardy, E, Liu, W, Thompson, A.A, Huang, X.P, Carroll, F.I, Mascarella, S.W, Westkaemper, R.B, Mosier, P.D, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
登録日2012-02-01
公開日2012-03-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献tructure of the human kappa-opioid receptor in complex with JDTic
Nature, 485, 2012
5UNH
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BU of 5unh by Molmil
Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)
分子名称: N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide, Soluble cytochrome b562,Type-2 angiotensin II receptor
著者Zhang, H, Han, G.W, Batyuk, A, Ishchenko, A, White, K.L, Patel, N, Sadybekov, A, Zamlynny, B, Rudd, M.T, Hollenstein, K, Tolstikova, A, White, T.A, Hunter, M.S, Weierstall, U, Liu, W, Babaoglu, K, Moore, E.L, Katz, R.D, Shipman, J.M, Garcia-Calvo, M, Sharma, S, Sheth, P, Soisson, S.M, Stevens, R.C, Katritch, V, Cherezov, V.
登録日2017-01-30
公開日2017-04-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
6DO1
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BU of 6do1 by Molmil
Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-like peptide S1I8, ...
著者Wingler, L.M, McMahon, C, Staus, D.P, Lefkowitz, R.J, Kruse, A.C.
登録日2018-06-08
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
Cell, 176, 2019
6PH7
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BU of 6ph7 by Molmil
Crystal structure of bovine opsin with nerol bound
分子名称: (2Z)-3,7-dimethylocta-2,6-dien-1-ol, G protein CT2 peptide, PALMITIC ACID, ...
著者Eger, B.T, Morizumi, T, Ernst, O.P.
登録日2019-06-25
公開日2020-07-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Odorant-binding site in visual opsin
To Be Published
6PGS
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BU of 6pgs by Molmil
Crystal structure of bovine opsin with geraniol bound
分子名称: G alpha CT2 peptide, Geraniol, PALMITIC ACID, ...
著者Eger, B.T, Morizumi, T, Ernst, O.P.
登録日2019-06-24
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.905 Å)
主引用文献Odorant-binding site in visual opsin
To Be Published
8WRB
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BU of 8wrb by Molmil
Lysophosphatidylserine receptor GPR34-Gi complex
分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Gong, W, Liu, G, Li, X, Wang, Y, Zhang, X.
登録日2023-10-13
公開日2023-11-08
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Plos Biol., 21, 2023
8HMV
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Structure of GPR21-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Wong, T.S, Gao, W.
登録日2022-12-05
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Cryo-EM structure of orphan G protein-coupled receptor GPR21.
MedComm (2020), 4, 2023
6DRY
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BU of 6dry by Molmil
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ...
著者McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L.
登録日2018-06-13
公開日2018-08-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.918 Å)
主引用文献Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
8J6I
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Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
分子名称: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X.
登録日2023-04-26
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.
Cell Rep, 42, 2023
8PM2
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BU of 8pm2 by Molmil
Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein
分子名称: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Gusach, A, Lee, Y, Edwards, P.C, Huang, F, Weyand, S.N, Tate, C.G.
登録日2023-06-28
公開日2023-08-09
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.
Biorxiv, 2023
7YM8
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Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline
分子名称: CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ...
著者Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
登録日2022-07-27
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
6Z4Q
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Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
分子名称: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.923 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
8IZ4
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BU of 8iz4 by Molmil
Lysophosphatidylserine receptor GPR34-Gi complex
分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Gong, W, Liu, G, Li, X, Zhang, X.
登録日2023-04-06
公開日2024-04-10
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors
To Be Published
8FYL
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Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
分子名称: 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D.
登録日2023-01-26
公開日2024-05-15
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024

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