2ABE
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![BU of 2abe by Molmil](/molmil-images/mine/2abe) | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators | 分子名称: | Carbonic anhydrase II, HISTIDINE, MERCURY (II) ION, ... | 著者 | Temperini, C, Scozzafava, A, Puccetti, L, Supuran, C.T. | 登録日 | 2005-07-15 | 公開日 | 2005-10-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with l-histidine as a platform for the design of stronger activators. Bioorg.Med.Chem.Lett., 15, 2005
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3D93
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![BU of 3d93 by Molmil](/molmil-images/mine/3d93) | |
3D92
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![BU of 3d92 by Molmil](/molmil-images/mine/3d92) | Human carbonic anhydrase II bound with substrate carbon dioxide | 分子名称: | CARBON DIOXIDE, GLYCEROL, ZINC ION, ... | 著者 | Domsic, J.F, Avvaru, B.S, McKenna, R. | 登録日 | 2008-05-26 | 公開日 | 2008-09-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Entrapment of carbon dioxide in the active site of carbonic anhydrase II J.Biol.Chem., 283, 2008
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3EFI
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![BU of 3efi by Molmil](/molmil-images/mine/3efi) | Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV | 分子名称: | Carbonic anhydrase 2, MERCURIBENZOIC ACID, TRYPTOPHAN, ... | 著者 | Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T. | 登録日 | 2008-09-09 | 公開日 | 2008-09-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV Bioorg.Med.Chem., 16, 2008
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3MNU
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![BU of 3mnu by Molmil](/molmil-images/mine/3mnu) | |
3BL0
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![BU of 3bl0 by Molmil](/molmil-images/mine/3bl0) | Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies | 分子名称: | 1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... | 著者 | Temperini, C, Supuran, C.T, Blackburn, G.M. | 登録日 | 2007-12-10 | 公開日 | 2008-01-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 18, 2008
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3BL1
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![BU of 3bl1 by Molmil](/molmil-images/mine/3bl1) | Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications | 分子名称: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, Carbonic anhydrase 2, MERCURY (II) ION, ... | 著者 | Temperini, C, Cecchi, A, Supuran, C.T. | 登録日 | 2007-12-10 | 公開日 | 2008-07-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg.Med.Chem.Lett., 18, 2008
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3B4F
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![BU of 3b4f by Molmil](/molmil-images/mine/3b4f) | Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies | 分子名称: | 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide, Carbonic anhydrase 2, MERCURY (II) ION, ... | 著者 | Guzel, o, Temperini, c, Innocenti, a, Scozzafava, A, Salman, a, Supuran, c.t. | 登録日 | 2007-10-24 | 公開日 | 2008-01-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 18, 2008
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2VVB
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![BU of 2vvb by Molmil](/molmil-images/mine/2vvb) | Human carbonic anhydrase II in complex with bicarbonate | 分子名称: | BICARBONATE ION, CARBON DIOXIDE, CARBONIC ANHYDRASE 2, ... | 著者 | Sjoeblom, B, Polentarutti, M, Djinovic-Carugo, K. | 登録日 | 2008-06-04 | 公開日 | 2009-07-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Structural Study of X-Ray Induced Activation of Carbonic Anhydrase. Proc.Natl.Acad.Sci.USA, 106, 2009
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2CAB
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![BU of 2cab by Molmil](/molmil-images/mine/2cab) | STRUCTURE, REFINEMENT AND FUNCTION OF CARBONIC ANHYDRASE ISOZYMES. REFINEMENT OF HUMAN CARBONIC ANHYDRASE I | 分子名称: | CARBONIC ANHYDRASE FORM B, ZINC ION | 著者 | Kannan, K.K, Ramanadham, M, Jones, T.A. | 登録日 | 1983-10-05 | 公開日 | 1984-02-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure, refinement, and function of carbonic anhydrase isozymes: refinement of human carbonic anhydrase I Ann.N.Y.Acad.Sci., 429, 1984
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4Z0Q
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![BU of 4z0q by Molmil](/molmil-images/mine/4z0q) | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) | 分子名称: | 4-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Pospisilova, K, Rezacova, P, Pachl, P. | 登録日 | 2015-03-26 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102, 2015
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4Z1J
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![BU of 4z1j by Molmil](/molmil-images/mine/4z1j) | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) | 分子名称: | 4-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Pospisilova, K, Rezacova, P, Pachl, P. | 登録日 | 2015-03-27 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102, 2015
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4Z1N
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![BU of 4z1n by Molmil](/molmil-images/mine/4z1n) | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) | 分子名称: | 4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)carbonyl]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Pospisilova, K, Rezacova, P, Pachl, P. | 登録日 | 2015-03-27 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102, 2015
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4Z1E
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![BU of 4z1e by Molmil](/molmil-images/mine/4z1e) | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) | 分子名称: | 6-methoxy-1-(4-sulfamoylbenzoyl)quinolinium, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Pospisilova, K, Rezacova, P, Pachl, P. | 登録日 | 2015-03-27 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102, 2015
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4Z1K
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![BU of 4z1k by Molmil](/molmil-images/mine/4z1k) | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) | 分子名称: | 4-[(6,7-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Pospisilova, K, Rezacova, P, Pachl, P. | 登録日 | 2015-03-27 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102, 2015
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2AW1
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![BU of 2aw1 by Molmil](/molmil-images/mine/2aw1) | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib | 分子名称: | 4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase II, ... | 著者 | Di Fiore, A, Pedone, C, D'Ambrosio, K, Scozzafava, A, De Simone, G, Supuran, C.T. | 登録日 | 2005-08-31 | 公開日 | 2006-07-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II Bioorg.Med.Chem.Lett., 16, 2006
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2O4Z
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![BU of 2o4z by Molmil](/molmil-images/mine/2o4z) | Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor | 分子名称: | Carbonic anhydrase 2, MERCURY (II) ION, N-hydroxysulfamide, ... | 著者 | Temperini, C, Winum, J.Y, Montero, J.L, Scozzafava, a, Supuran, c.t. | 登録日 | 2006-12-05 | 公開日 | 2007-05-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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3K7K
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![BU of 3k7k by Molmil](/molmil-images/mine/3k7k) | |
6I0J
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![BU of 6i0j by Molmil](/molmil-images/mine/6i0j) | Crystal structure of human carbonic anhydrase I in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor | 分子名称: | ACETATE ION, Carbonic anhydrase 1, GLYCEROL, ... | 著者 | Ferraroni, M, Supuran, C.T, Bozdag, M, Chiapponi, D. | 登録日 | 2018-10-26 | 公開日 | 2019-11-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. Eur.J.Med.Chem., 182, 2019
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6I0L
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![BU of 6i0l by Molmil](/molmil-images/mine/6i0l) | Crystal structure of human carbonic anhydrase I in complex with the 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-(4-sulfamoylphenyl)ethyl]urea inhibitor | 分子名称: | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[2-(4-sulfamoylphenyl)ethyl]urea, ACETATE ION, Carbonic anhydrase 1, ... | 著者 | Ferraroni, M, Supuran, C.T, Bozdag, M, Chiapponi, D. | 登録日 | 2018-10-26 | 公開日 | 2019-11-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. Eur.J.Med.Chem., 182, 2019
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3DD8
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![BU of 3dd8 by Molmil](/molmil-images/mine/3dd8) | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies | 分子名称: | 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate, Carbonic anhydrase 2, MERCURY (II) ION, ... | 著者 | Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T. | 登録日 | 2008-06-05 | 公開日 | 2008-08-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies Bioorg.Med.Chem.Lett., 18, 2008
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1ZE8
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![BU of 1ze8 by Molmil](/molmil-images/mine/1ze8) | Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor | 分子名称: | 1-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}-2,4,6-TRIMETHYLPYRIDINIUM, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase II, ... | 著者 | Menchise, V, De Simone, G, Alterio, V, Di Fiore, A, Pedone, C, Scozzafava, A, Supuran, C.T. | 登録日 | 2005-04-18 | 公開日 | 2005-10-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II J.Med.Chem., 48, 2005
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3F4X
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![BU of 3f4x by Molmil](/molmil-images/mine/3f4x) | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference | 分子名称: | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Carbonic anhydrase 2, MERCURY (II) ION, ... | 著者 | Temperini, C, Cecchi, A, Scozzafava, A, Supuran, C.T. | 登録日 | 2008-11-03 | 公開日 | 2009-03-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. J.Med.Chem., 52, 2009
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3CAJ
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![BU of 3caj by Molmil](/molmil-images/mine/3caj) | |
4XIX
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![BU of 4xix by Molmil](/molmil-images/mine/4xix) | Carbonic anhydrase Cah3 from Chlamydomonas reinhardtii in complex with phosphate. | 分子名称: | Carbonic anhydrase, alpha type, DIHYDROGENPHOSPHATE ION, ... | 著者 | Hainzl, T, Grundstrom, C, Benlloch, R, Shevela, D, Shutova, T, Messinger, J, Samuelsson, G, Sauer-Eriksson, A.E. | 登録日 | 2015-01-08 | 公開日 | 2015-02-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure and Functional Characterization of Photosystem II-Associated Carbonic Anhydrase CAH3 in Chlamydomonas reinhardtii. Plant Physiol., 167, 2015
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