3DD8

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

Summary for 3DD8

Entry DOI	10.2210/pdb3dd8/pdb
Related	1TTM
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, antiglaucoma, oao-acid, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29926.53
Authors	Temperini, C.,Innocenti, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2008-06-05, release date: 2008-08-12, Last modification date: 2023-11-01)
Primary citation	Temperini, C.,Innocenti, A.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies Bioorg.Med.Chem.Lett., 18:4282-4286, 2008 Cited by PubMed: 18640037 DOI: 10.1016/j.bmcl.2008.06.105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation