2AW1
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib
Summary for 2AW1
Entry DOI | 10.2210/pdb2aw1/pdb |
Related | 1CA2 1OQ5 |
Descriptor | Carbonic anhydrase II, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (6 entities in total) |
Functional Keywords | carbonic anhydrase, protein-inhibitor complex, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30060.53 |
Authors | Di Fiore, A.,Pedone, C.,D'Ambrosio, K.,Scozzafava, A.,De Simone, G.,Supuran, C.T. (deposition date: 2005-08-31, release date: 2006-07-04, Last modification date: 2023-10-25) |
Primary citation | Di Fiore, A.,Pedone, C.,D'Ambrosio, K.,Scozzafava, A.,De Simone, G.,Supuran, C.T. Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II Bioorg.Med.Chem.Lett., 16:437-442, 2006 Cited by PubMed: 16290146DOI: 10.1016/j.bmcl.2005.09.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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