1OQ5

CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR

Summary for 1OQ5

Entry DOI	10.2210/pdb1oq5/pdb
Related	1CIL
Descriptor	Carbonic anhydrase II, ZINC ION, 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, ... (4 entities in total)
Functional Keywords	10-stranded, twisted beta-sheet, metal binding protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29604.64
Authors	Weber, A.,Casini, A.,Heine, A.,Kuhn, D.,Supuran, C.T.,Scozzafava, A.,Klebe, G. (deposition date: 2003-03-07, release date: 2004-03-23, Last modification date: 2023-08-16)
Primary citation	Weber, A.,Casini, A.,Heine, A.,Kuhn, D.,Supuran, C.T.,Scozzafava, A.,Klebe, G. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J.Med.Chem., 47:550-557, 2004 Cited by PubMed: 14736236 DOI: 10.1021/jm030912m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation