3F4X
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference
Summary for 3F4X
Entry DOI | 10.2210/pdb3f4x/pdb |
Related | 3BL1 |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitors, diuretics, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29893.83 |
Authors | Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2008-11-03, release date: 2009-03-17, Last modification date: 2023-11-01) |
Primary citation | Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. J.Med.Chem., 52:322-328, 2009 Cited by PubMed: 19115843DOI: 10.1021/jm801386n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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