3BL1

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications

Summary for 3BL1

Entry DOI	10.2210/pdb3bl1/pdb
Related	2EU2 2EU3 3BL0
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, diuretics, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid)
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29920.90
Authors	Temperini, C.,Cecchi, A.,Supuran, C.T. (deposition date: 2007-12-10, release date: 2008-07-01, Last modification date: 2024-02-21)
Primary citation	Temperini, C.,Cecchi, A.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg.Med.Chem.Lett., 18:2567-2573, 2008 Cited by PubMed: 18374572 DOI: 10.1016/j.bmcl.2008.03.051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation