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6I0J

Crystal structure of human carbonic anhydrase I in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor

Summary for 6I0J
Entry DOI10.2210/pdb6i0j/pdb
DescriptorCarbonic anhydrase 1, ZINC ION, ACETATE ION, ... (6 entities in total)
Functional Keywordscarbonic anhydrase i, inhibitor, lyase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight59157.10
Authors
Ferraroni, M.,Supuran, C.T.,Bozdag, M.,Chiapponi, D. (deposition date: 2018-10-26, release date: 2019-11-20, Last modification date: 2024-01-24)
Primary citationBozdag, M.,Ferraroni, M.,Ward, C.,Carta, F.,Bua, S.,Angeli, A.,Langdon, S.P.,Kunkler, I.H.,Al-Tamimi, A.S.,Supuran, C.T.
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.
Eur.J.Med.Chem., 182:111600-111600, 2019
Cited by
PubMed: 31419777
DOI: 10.1016/j.ejmech.2019.111600
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation

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