1ZE8

Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor

Summary for 1ZE8

Entry DOI	10.2210/pdb1ze8/pdb
Descriptor	Carbonic anhydrase II, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (6 entities in total)
Functional Keywords	twisted beta-sheet, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29959.49
Authors	Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T. (deposition date: 2005-04-18, release date: 2005-10-18, Last modification date: 2024-03-13)
Primary citation	Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II J.Med.Chem., 48:5721-5727, 2005 Cited by PubMed: 16134940 DOI: 10.1021/jm050333c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation